Article

Allelic Variation at 9p21.3 Orchestrates Widespread RNA Splicing Shifts Governing Vascular Smooth Muscle Cell Plasticity

2026-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Genetic risk for coronary artery disease (CAD) has been linked to variants across more than 300 genomic loci. Whether and how these loci interface with RNA processing to drive disease-relevant cellular phenotypes remains unknown. Here, we applied haplotype-biased genome editing in induced pluripotent stem cells (iPSCs), followed by differentiation into vascular smooth muscle cells (VSMCs), to ad...

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Literature Corpus work: e3fe3437-e79e-5a07-b50c-a7db5f27ff33
DOI: 10.64898/2026.01.14.699552

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