Article

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

2018-04-30

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWAS) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret these loci, we generated transcriptome and whole-genome datasets using human coronary artery smooth muscle cells (HCASMC) from 52 unrelated donors, as well as epigeno...

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Literature Corpus work: 559d5f12-ae89-537b-8cfb-f480de8961bc
DOI: 10.1101/309559

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