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Article

Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2023

Mayner Jaimie M, Masutani Evan M, Demeester Elena, Kumar Aditya, Macapugay Gail, Beri Pranjali, Lo Sardo Valentina, Engler Adam J

Abstract excerpt

9p21.3 locus polymorphisms have the strongest correlation with coronary artery disease, but as a noncoding locus, disease connection is enigmatic. The lncRNA ANRIL found in 9p21.3 may regulate vascular smooth muscle cell (VSMC) phenotype to contribute to disease risk. We observed significant heterogeneity in induced pluripotent stem cell-derived VSMCs from patients homozygous for risk versus isogenic knockout or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Identifiers

PMID: 37276403
DOI: 10.1073/pnas.2217122120
PMCID: PMC10268236

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