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Article

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci.

American journal of human genetics - 6 Sept 2018

Liu Boxiang, Pjanic Milos, Wang Ting, Nguyen Trieu, Gloudemans Michael, Rao Abhiram, Castano Victor G, Nurnberg Sylvia, Rader Daniel J, Elwyn Susannah, Ingelsson Erik, Montgomery Stephen B, Miller Clint L, Quertermous Thomas

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWASs) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret these loci, we generated transcriptome and whole-genome datasets using human coronary artery smooth muscle cells (HCASMCs) from 52 unrelated donors, as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30146127
DOI: 10.1016/j.ajhg.2018.08.001
PMCID: PMC6128252

Genes

CAD
PDGFRA
SIPA1
FES
SMAD3
TCF21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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