Article

Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes

2022-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies (GWAS) have identified over 175 loci associated with CAD. The majority of these loci are in non-coding regions and are predicted to regulate gene expression. Given that vascular smooth muscle cells (SMCs) play critical roles in the development and progression of CAD, we...

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Literature Corpus work: b68cf85c-ff22-5f83-bb62-94319c2f43c2
DOI: 10.1101/2022.01.24.477536

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