Article

The <i>9p21.3</i> Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of <i>MTAP</i>

2025-11-18

Abstract excerpt

<h4>Summary</h4> The 9p21.3 locus is the strongest genetic association with coronary artery disease (CAD), yet its causal mechanisms remain unresolved. We map the regulatory architecture of 9p21.3 in disease-relevant vascular cells, identifying 12 enhancers within the CAD risk haplotype that respond dynamically to inflammatory and metabolic stress in fibroblasts and smooth muscle cells. These activated states a...

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Literature Corpus work: c2d0ee19-c8d5-5744-b736-9a3a829df191
DOI: 10.1101/2025.11.18.689066

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