Article
The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.
PloS one - 1 Jan 2012
Pilbrow Anna P, Folkersen Lasse, Pearson John F, Brown Chris M, McNoe Les, Wang Nancy M, Sweet Wendy E, Tang W H Wilson, Black Michael A, Troughton Richard W, Richards A Mark, Franco-Cereceda Anders, Gabrielsen Anders, Eriksson Per, Moravec Christine S, Cameron Vicky A
Abstract excerpt
Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at 9p21.3, the nearest genes being CDKN2A and CDKN2B. To understand the pathways by which this locus might influence CAD susceptibility, we investigated associations between the 9p21.3 risk genotype and global gene expression in heart tissue from donors with no diagnosed heart disease (n = 108,...
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