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Article

The 9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2025

Salido Elsa, de Medeiros Vieira Carolina, Mosquera Jose Verdezoto, Zade Rohan, Parikh Parth, Suryavanshi Shraddha, Miller Clint L, Lo Sardo Valentina

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human genomic loci linked to coronary artery disease susceptibility. Among these genomic regions, the most impactful is the 9p21.3 coronary artery disease risk locus, which spans a 60-kb gene desert and encompasses ≈80 SNPs (single nucleotide polymorphism) in high linkage disequilibrium. Despite ≈2 decades since its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40143812
DOI: 10.1161/ATVBAHA.124.322045
PMCID: PMC12017600

Genes

CRABP1
LIMCH1

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