Article

The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state

2024-05-30

Abstract excerpt

<h4>Background</h4> Genome-wide association studies have identified common genetic variants at ∼300 human genomic loci linked to coronary artery disease (CAD) susceptibility. Among these genomic regions, the most impactful is the 9p21.3 CAD risk locus, which spans a 60 kb gene desert and encompasses ∼80 SNPs in high linkage disequilibrium. Despite nearly two decades since its discovery, the role of the 9p21.3 loc...

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Literature Corpus work: f2727d5c-e21a-5828-8981-2185228fc246
DOI: 10.1101/2024.05.25.595888

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