Article

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk

2021-06-07

Abstract excerpt

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across several cell types. Genome-wide association studies (GWAS) have identified over 170 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis -regulatory elements (CREs). Here, we applied single-cell ATAC-seq to profile 28,316 cells across coronary artery segments...

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Literature Corpus work: baf58333-5546-5c84-a675-065c6e6c137c
DOI: 10.1101/2021.06.07.447388

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