Article

Factorization of Alzheimer’s disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responses

2026-01-08

Abstract excerpt

Late-onset Alzheimer’s disease (AD) is a complex and heterogeneous neurodegenerative disease with significant genetic components implicated in at least 97 loci from AD genome-wide association studies. While various distinct AD subtypes have been identified based on brain or CSF molecular profiling, contribution of the genetic signatures in distinguishing the AD subtypes is lacking. Here, we leveraged large snRNA-s...

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Literature Corpus work: e3b4db9b-632c-5824-a0e1-4c5d52462e7d
DOI: 10.64898/2026.01.02.697432

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