Article

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer’s disease

2026-02-06

Abstract excerpt

Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer’s disease (AD), but whether these programs differ between clinical symptoms and neuropathological burden remains unclear. Using single-nucleus RNA sequencing (snRNA-seq) from the dorsolateral prefrontal cortex of 48 donors either with AD or controls (∼70,000 nuclei), we integrated transcriptomic, genetic, and demogr...

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Literature Corpus work: 5576e3a3-d92f-5df6-a636-734924208a42
DOI: 10.64898/2026.01.31.26345282

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