Article

Microglia-specific polygenic risk stratification reveals distinct pathological subtypes in Alzheimer’s disease

2025-10-07

Abstract excerpt

<h4>INTRODUCTION</h4> Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder in which numerous common variants collectively influence risk. Polygenic risk scores (PRSs) quantify this genetic predisposition, but conventional PRS approaches aggregate biologically diverse variants, potentially masking cell type–specific contributions. <h4>METHODS</h4> We developed PRSs for major brain cell types and...

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Literature Corpus work: 0272afee-160e-5a0c-992c-ea84c867f4f8
DOI: 10.1101/2025.10.06.25336925

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