Article

A landscape of the genetic and cellular heterogeneity in Alzheimer disease

2021-12-02

Abstract excerpt

<h4>Background</h4> Alzheimer disease (AD) has substantial genetic, molecular, and cellular heterogeneity associated with its etiology. Much of our current understanding of the main AD molecular events associated with the amyloid hypothesis ( APP, PSEN1 and PSEN2 ) and neuroimmune modulation ( TREM2 and MS4A ) is based on genetic studies including GWAS. However, the functional genes, downstream transcriptional ram...

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Literature Corpus work: 1b09b5dc-c6e9-5828-be9c-ac576a51b3d9
DOI: 10.1101/2021.11.30.21267072

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