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Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domains

1 Apr 2024

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is the predominant dementia globally, with heterogeneous presentation and penetrance of clinical symptoms, variable presence of mixed pathologies, potential disease subtypes, and numerous associated endophenotypes. Beyond the difficulty of designing treatments that address the core pathological characteristics of the disease, therapeutic development is challenged by the...

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PMID: 38650747
DOI: 10.1002/trc2.12461

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