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Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms.

Scientific reports - 15 Oct 2021

Wang Zhen, Zhang Quanwei, Lin Jhih-Rong, Jabalameli M Reza, Mitra Joydeep, Nguyen Nha, Zhang Zhengdong D

Abstract excerpt

Alzheimer's disease (AD) is a genetically complex, multifactorial neurodegenerative disease. It affects more than 45 million people worldwide and currently remains untreatable. Although genome-wide association studies (GWAS) have identified many AD-associated common variants, only about 25 genes are currently known to affect the risk of developing AD, despite its highly polygenic nature. Moreover, the risk...

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PMID: 34654853
DOI: 10.1038/s41598-021-99352-3
PMCID: PMC8519945

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