Article

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics

2023-09-30

Abstract excerpt

<h4>Summary/Abstract</h4> The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNAseq and ATACseq in Alzheimer disease (AD), Frontotemporal degeneration (FTD), and Progressive Supranuclear Palsy (PSP), analyzing 40 participants, yielding over 1.4M cells from three brain regions ranging in...

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Literature Corpus work: dfbd18a4-78c1-5bf8-820a-b0abe04c378c
DOI: 10.1101/2023.09.29.560245

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