Article

Molecular mechanism decipher of Alzheimer’s disease based on single-cell RNA-seq information

2025-11-25

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is a most common age-related neurodegenerative disease with no effective treatments, is one of the leading contributions to global disease burden. AD is represented by complicated biological mechanisms and complexity of brain tissues, often manifested histologically by the parenchymal deposition of amyloid-beta (Aβ) plaques, the formation of neurofibrillary tangles and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d608f68-8c3f-559e-8445-22e1fa743d56
DOI: 10.1101/2025.11.22.689872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanism decipher of Alzheimer’s disease based on single-cell RNA-seq informationDOI 10.1101/2025.11.22.689872Read

Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s DiseaseSemantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

Single-cell multiomics reveals disrupted glial gene regulatory programs in Alzheimer’s disease via interpretable machine learningSemantic proximity Read

Identification of plasma cell subsets and molecular markers of Alzheimer's disease based on single-cell weighted gene co-expression network analysis and Mendelian randomization analysisSemantic proximity Read

Single-cell transcriptomic analysis of Alzheimer’s diseaseSemantic proximity Read

Early neuronal reprogramming and cell cycle reentry shape Alzheimer’s disease progressionSemantic proximity Read

Factorization of Alzheimer’s disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responsesSemantic proximity Read

Combining machine learning algorithms and single-cell data to study the pathogenesis of Alzheimer’s diseaseSemantic proximity Read

Elucidating the Functional Roles of Long Non-coding RNAs in Alzheimer's DiseaseSemantic proximity Read

scREAD: A single-cell RNA-Seq database for Alzheimer’s DiseaseSemantic proximity Read

Molecular subtyping of Alzheimer's disease with consensus non-negative matrix factorization.Semantic proximity Read

An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease.Semantic proximity Read