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Article

Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.

Medicine - 15 Nov 2024

Huang Chao, Zhou Ruihao, Huang Xingya, Dai Fanshu, Zhang Biao

Abstract excerpt

In this study, we aimed to delineate cellular heterogeneity in Alzheimer's disease (AD) and identify genetic markers contributing to its pathogenesis using integrative analysis of single-nucleus RNA sequencing (sn-RNA-Seq) and Mendelian randomization (MR). The dorsolateral prefrontal cortex sn-RNA-Seq dataset (GSE243292) was sourced from the Gene Expression Omnibus (GEO) database. Data preprocessing was conducted...

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Identifiers

PMID: 39560568
DOI: 10.1097/MD.0000000000040551
PMCID: PMC11575974

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