Article

Coupling CRISPR Scanning with Targeted Chromatin Accessibility Profiling using a Double-Stranded DNA Deaminase

2024-12-18

Abstract excerpt

Genome editing enables sequence-function profiling of endogenous cis-regulatory elements, driving understanding of their mechanisms and the development of gene therapies. However, these approaches cannot be combined with direct scalable readouts of chromatin structure and accessibility across long single-molecule chromatin fibers. Here we leverage a double-stranded DNA cytosine deaminase to profile chromatin acces...

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Literature Corpus work: e3246a5b-247c-5e25-b072-ab8eab90f698
DOI: 10.1101/2024.12.17.628791

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