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Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

31 Jan 2026

Abstract excerpt

BACKGROUND: CRISPR/dCas9-based epigenome editing systems, including DNA methylation epimodifiers, have greatly advanced molecular functional studies, revolutionizing their precision and applicability. Despite their promise, challenges such as the magnitude and stability of the on-target editing and unwanted off-target effects underscore the need for improved tool characterization and design. RESULTS: We...

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PMID: 41620608
DOI: 10.1186/s13059-026-03967-6

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