Article

Human genetic diversity alters therapeutic gene editing off-target outcomes

2021-05-21

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR gene editing holds great promise to modify somatic genomes to ameliorate disease. In silico prediction of homologous sites coupled with biochemical evaluation of possible genomic off-targets may predict genotoxicity risk of individual gene editing reagents. However, standard computational and biochemical methods focus on reference genomes and do not consider the impact of genetic diversit...

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Literature Corpus work: a0b6ea4a-5aae-5a38-b334-b5297983c295
DOI: 10.1101/2021.05.20.445054

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