Article

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

2021-04-05

Abstract excerpt

Defining off-target profiles of gene-editing nucleases and CRISPR base editors remains an important challenge for use of these technologies, therapeutic or otherwise. Existing methods can identify off-target sites induced by these gene editors on an individual genome but are not designed to account for the broad diversity of genomic sequence variation that exists within populations of humans or other organisms. He...

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Literature Corpus work: 790e43fa-2bd1-532f-901d-185fd2ec8d2f
DOI: 10.1101/2021.04.05.438458

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