Article
From profiles to function in epigenomics.
Nature reviews. Genetics - 1 Jan 2017
Stricker Stefan H, Köferle Anna, Beck Stephan
Abstract excerpt
Myriads of epigenomic features have been comprehensively profiled in health and disease across cell types, tissues and individuals. Although current epigenomic approaches can infer function for chromatin marks through correlation, it remains challenging to establish which marks actually have causative roles in gene regulation and other processes. After revisiting how classical approaches have addressed this...
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