Article

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

2020-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Cytokines are highly pleiotropic ligands that critically contribute to a balanced immune response. We have an incomplete understanding of how cytokines elicit their functional pleiotropy, which has limited their therapeutic use. Here, using Interleukin-6 (IL-6) as a model system, we have performed detailed phosphoproteomic and transcriptomic studies in human Th-1 cells to address the molecular b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2e4866e-4c0a-5e0c-98ea-676720c0fa9b
DOI: 10.1101/2020.03.19.998351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene lociDOI 10.1101/2020.03.19.998351Read

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4 <sup>+</sup> T Cell Effector FunctionSemantic proximity Read

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disordersSemantic proximity Read

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.Semantic proximity Read

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolismSemantic proximity Read

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.Semantic proximity Read

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6Semantic proximity Read

Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiationSemantic proximity Read

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenzaSemantic proximity Read

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.Semantic proximity Read

STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment.Semantic proximity Read

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responsesSemantic proximity Read

PIM kinases regulate early human Th17 cell differentiationSemantic proximity Read