Article
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
The Journal of experimental medicine - 25 Jul 2016
Ma Cindy S, Wong Natalie, Rao Geetha, Nguyen Akira, Avery Danielle T, Payne Kathryn, Torpy James, O'Young Patrick, Deenick Elissa, Bustamante Jacinta, Puel Anne, Okada Satoshi, Kobayashi Masao, Martinez-Barricarte Ruben, Elliott Michael, Sebnem Kilic Sara, El Baghdadi Jamila, Minegishi Yoshiyuki, Bousfiha Aziz, Robertson Nic, Hambleton Sophie, Arkwright Peter D, French Martyn, Blincoe Annaliesse K, Hsu Peter, Campbell Dianne E, Stormon Michael O, Wong Melanie, Adelstein Stephen, Fulcher David A, Cook Matthew C, Stepensky Polina, Boztug Kaan, Beier Rita, Ikincioğullari Aydan, Ziegler John B, Gray Paul, Picard Capucine, Boisson-Dupuis Stéphanie, Phan Tri Giang, Grimbacher Bodo, Warnatz Klaus, Holland Steven M, Uzel Gulbu, Casanova Jean-Laurent, Tangye Stuart G
Abstract excerpt
Naive CD4(+) T cells differentiate into specific effector subsets-Th1, Th2, Th17, and T follicular helper (Tfh)-that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human primary immunodeficiencies on these processes, and how they compromise specific immune responses, remain...
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