Article

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders

2021-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. We found that IL-27 induces more sustained STAT1 phosphorylation than IL-6, with the two cytokines inducing comparable levels of STAT3 phosphory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b225bfe7-a240-52ce-a8a3-7c404c16b8fa
DOI: 10.1101/2021.01.08.425379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disordersDOI 10.1101/2021.01.08.425379Read

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.Semantic proximity Read

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responsesSemantic proximity Read

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.Semantic proximity Read

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.Semantic proximity Read

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene lociSemantic proximity Read

Cytokine receptor signaling through the Jak–Stat–Socs pathway in diseaseSemantic proximity Read

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modellingSemantic proximity Read

STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancerSemantic proximity Read

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic InterventionSemantic proximity Read

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional ConsequencesSemantic proximity Read

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6Semantic proximity Read

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27Semantic proximity Read