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Article

STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment.

International journal of hematology - 1 Mar 2024

Benoit Alexandre, Abraham Madelyn J, Li Sheena, Kim John, Estrada-Tejedor Roger, Bakadlag Rowa, Subramaniam Nivetha, Makhani Kiran, Guilbert Cynthia, Tu Raymond, Salaciak Matthew, Klein Kathleen Oros, Coyle Krysta Mila, Hilton Laura K, Santiago Raoul, Dmitrienko Svetlana, Assouline Sarit, Morin Ryan D, Del Rincon Sonia V, Johnson Nathalie A, Mann Koren K

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) relapses in approximately 40% of patients following frontline therapy. We reported that STAT6D419 mutations are enriched in relapsed/refractory DLBCL (rrDLBCL) samples, suggesting that JAK/STAT signaling plays a role in therapeutic resistance. We hypothesized that STAT6D419 mutations can improve DLBCL cell survival by reprogramming the microenvironment to sustain STAT6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38285120
DOI: 10.1007/s12185-023-03692-x
PMCID: PMC10920476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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