Article
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.
eLife - 19 Apr 2021
Wilmes Stephan, Jeffrey Polly-Anne, Martinez-Fabregas Jonathan, Hafer Maximillian, Fyfe Paul K, Pohler Elizabeth, Gaggero Silvia, López-García Martín, Lythe Grant, Taylor Charles, Guerrier Thomas, Launay David, Mitra Suman, Piehler Jacob, Molina-París Carmen, Moraga Ignacio
Abstract excerpt
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. We found that IL-27 induces more sustained STAT1 phosphorylation than IL-6, with the two cytokines inducing comparable levels of STAT3 phosphorylation....
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