Article

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responses

2026-06-07

Abstract excerpt

IL-10 is a key anti-inflammatory cytokine whose activity is impaired in autoimmune diseases. However, IL-10 also promotes inflammation under certain conditions, limiting the efficacy of IL-10-based therapies. Because the principles underlying these opposing effects remain unclear, we developed a mathematical model of the IL-10 signaling pathway to understand how such pleiotropic responses arise. Considering that S...

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Literature Corpus work: f4d2aeba-8ac0-5393-b11c-78b04700df87
DOI: 10.64898/2026.06.02.729479

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