Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIM kinases regulate early human Th17 cell differentiation

30 Nov 2023

Abstract excerpt

The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (i.e., PIM1, PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are downstream of several cytokine signaling pathways that drive immune-mediated diseases. Uncontrolled T helper 17 (Th17) cell activation has been associated with the pathogenesis of autoimmunity. However, the detailed molecular function of PIMs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Immune Cell Function and Interaction
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38039135
DOI: 10.1016/j.celrep.2023.113469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIM kinases regulate early human Th17 cell differentiationPMID 38039135Read ↗

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitisSemantic proximity Read ↗

Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeuticsSemantic proximity Read ↗

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.Semantic proximity Read ↗

A review on PIM kinases in tumorsSemantic proximity Read ↗

Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-α and lipopolysaccharide.Semantic proximity Read ↗

The PIM kinases in hematological cancersSemantic proximity Read ↗

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.Semantic proximity Read ↗

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation.Semantic proximity Read ↗

Serpine1 plays a critical role in Th17 cell differentiation and psoriasis pathogenesisSemantic proximity Read ↗

Targeting PIM Kinases to Overcome Therapeutic Resistance in CancerSemantic proximity Read ↗

Recent advances in understanding the molecular mechanisms of the development and function of <scp>T</scp>h17 cellsSemantic proximity Read ↗

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4 <sup>+</sup> T Cell Effector FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.