Article

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

2019-09-26

Abstract excerpt

Cytokine-induced signaling pathways are tightly regulated and self-limiting, as their dysregulation causes immune disorders and cancer. The precise mechanisms that fine-tune these responses are incompletely understood. We show that the E3 ubiquitin ligase RNF144A is an IL-2/STAT5-induced gene in T cells and critically orchestrates the hierarchy of IL-2R signaling to promote STAT5 activation and limit RAF-ERK-MAPK...

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Literature Corpus work: d3ac9f5e-a807-5173-b9db-f5d2a422ea36
DOI: 10.1101/782680

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