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Article

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6

1 Jun 2004

Abstract excerpt

Lymphokines interleukin-4 (IL4) and IL13 exert overlapping biological activities via the shared use of the IL4 receptor alpha-chain and signal transducer and activator of transcription 6 (Stat6). Stat6 is critical for T-helper 2 cell differentiation, B-cell Ig class switch, and allergic diseases; thus, understanding its regulation is of central importance. Phosphorylation is crucial for Stat activity. Whereas...

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PMID: 15069079
DOI: 10.1074/jbc.m313668200

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