Article
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
Immunity - 19 May 2015
Hirahara Kiyoshi, Onodera Atsushi, Villarino Alejandro V, Bonelli Michael, Sciumè Giuseppe, Laurence Arian, Sun Hong-Wei, Brooks Stephen R, Vahedi Golnaz, Shih Han-Yu, Gutierrez-Cruz Gustavo, Iwata Shigeru, Suzuki Ryo, Mikami Yohei, Okamoto Yoshitaka, Nakayama Toshinori, Holland Steven M, Hunter Christopher A, Kanno Yuka, O'Shea John J
Abstract excerpt
Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions. To evaluate the specificity and redundancy for these cytokines, we quantified their global transcriptomic changes and determined the relative contributions of STAT1 and STAT3 using genetic models and chromatin...
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