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Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiation

1 Jan 2025

Abstract excerpt

Dysregulated differentiation of naïve CD4+ T cells into T helper 17 (Th17) cells is likely a key factor predisposing to many autoimmune diseases. Therefore, better understanding how Th17 differentiation is regulated is essential to identify novel therapeutic targets and strategies to identify individuals at high risk of developing autoimmunity. Here, we extend our prior work using chemical inhibitors to provide...

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PMID: 39846842
DOI: 10.1093/immhor/vlae005

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