Article
Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.
Brain structure & function - 1 Jan 2024
Moon Hae Sol, Mahzarnia Ali, Stout Jacques, Anderson Robert J, Strain Madison, Tremblay Jessica T, Han Zay Yar, Niculescu Andrei, MacFarlane Anna, King Jasmine, Ashley-Koch Allison, Clark Darin, Lutz Michael W, Badea Alexandra
Abstract excerpt
APOE allelic variation is critical in brain aging and Alzheimer's disease (AD). The APOE2 allele associated with cognitive resilience and neuroprotection against AD remains understudied. We employed a multipronged approach to characterize the transition from middle to old age in mice with APOE2 allele, using behavioral assessments, image-derived morphometry and diffusion metrics, structural connectomics, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.