Article

Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous mice

2025-05-27

Abstract excerpt

Apolipoprotein-ε4 (APOE4) homozygosity is the strongest genetic risk-factor for Alzheimer's Disease (AD). The combined effects of APOE4 with age on the brain are unclear. In the present work, we tested the hypothesis that age alters contextual fear memory, functional network topology, diffusion imaging measures, and RNA expression differentially between APOE4 and APOE3 homozygous mice. Male and female mice, 1.5-5....

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Literature Corpus work: be3b2c6c-db88-5528-bf2e-3d7a95ef7d9a
DOI: 10.1101/2025.05.22.655620

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Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous miceDOI 10.1101/2025.05.22.655620Read

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