Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.

Magnetic resonance imaging - 1 Dec 2024

Winter Steven, Mahzarnia Ali, Anderson Robert J, Han Zay Yar, Tremblay Jessica, Stout Jacques A, Moon Hae Sol, Marcellino Daniel, Dunson David B, Badea Alexandra

Abstract excerpt

Alzheimer's disease (AD) presents complex challenges due to its multifactorial nature, poorly understood etiology, and late detection. The mechanisms through which genetic and modifiable risk factors influence disease susceptibility are under intense investigation, with APOE being the major genetic risk factor for late onset AD. Yet the impact of unique risk factors on brain networks is difficult to disentangle,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connectome
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Magnetic Resonance Imaging

Share to Mice, Transgenic

Share to Nerve Net

Source

Open in PubMed Open full text

Identifiers

PMID: 39362319
DOI: 10.1016/j.mri.2024.110251
PMCID: PMC11514054

Genes

APOE
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.PMID 39362319Read ↗

APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity Read ↗

Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.Semantic proximity Read ↗

Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse ModelsSemantic proximity Read ↗

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity Read ↗

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s DiseaseSemantic proximity Read ↗

Vulnerable Brain Networks Associated with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceSemantic proximity Read ↗

Selective vulnerability and resilience to Alzheimer’s disease tauopathy as a function of genes and the connectomeSemantic proximity Read ↗

Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous miceSemantic proximity Read ↗

APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.Semantic proximity Read ↗

Network-Level Organization of Systemic Inflammation Reflects Early Alzheimer’s-Like Behavioral ChangesSemantic proximity Read ↗

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.