Article

Isoflurane and surgery aggravate APOE4-dependent lipid dysregulation and neural dysfunction, leading to neurological impairment in male mice

2026-08-05

Abstract excerpt

<h4>Purpose</h4> Perioperative exposure to the volatile anesthetic isoflurane (ISO) has been associated with cognitive and olfactory deficits and may increase the risk of Alzheimer’s disease (AD). Apolipoprotein E4 (APOE4), the strongest genetic risk factor for AD, contributes to disease pathogenesis through disrupted lipid homeostasis. However, whether and how isoflurane interacts with APOE genotype to influence...

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Literature Corpus work: 575fdc01-de4b-51c5-a2ca-d3864bd2c799
DOI: 10.64898/2026.07.31.742028

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