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Article

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.

Neuron - 3 Jun 2020

Zhao Na, Ren Yingxue, Yamazaki Yu, Qiao Wenhui, Li Fuyao, Felton Lindsey M, Mahmoudiandehkordi Siamak, Kueider-Paisley Alexandra, Sonoustoun Berkiye, Arnold Matthias, Shue Francis, Zheng Jiaying, Attrebi Olivia N, Martens Yuka A, Li Zonghua, Bastea Ligia, Meneses Axel D, Chen Kai, Thompson J Will, St John-Williams Lisa, Tachibana Masaya, Aikawa Tomonori, Oue Hiroshi, Job Lucy, Yamazaki Akari, Liu Chia-Chen, Storz Peter, Asmann Yan W, Ertekin-Taner Nilüfer, Kanekiyo Takahisa, Kaddurah-Daouk Rima, Bu Guojun

Abstract excerpt

Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD): age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of brain transcriptomes and blood metabolomes from human apoE2-, apoE3-, and apoE4-targeted replacement mice across young, middle, and old ages with both sexes. We found that age had the greatest impact on brain transcriptomes highlighted by...

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Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Metabolome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protective Factors

Receptors, Immunologic

Unfolded Protein Response

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Identifiers

PMID: 32199103
DOI: 10.1016/j.neuron.2020.02.034
PMCID: PMC7388065

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