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Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H

2025-04-24

Abstract excerpt

Alzheimer’s Disease (AD) poses a significant global health challenge, being the most prominent cause of dementia with prevalence increasing as the population ages. While the majority of AD cases are late-onset (LOAD), current animal models predominantly represent the more aggressive, faster progressing early-onset AD (EOAD), limiting their ability in assessing early biomarkers and gaining deeper understanding of L...

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Literature Corpus work
aeefbec0-497e-581b-9955-3342b2c0a7b5
DOI
10.1101/2025.04.20.649712
Open publication

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