Article

Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse Models

2025-02-06

Abstract excerpt

Alzheimer’s disease (AD) lacks effective cures and is typically detected after substantial pathological changes have occurred, making intervention challenging. Early detection and understanding of risk factors and their downstream effects are therefore crucial. Animal models provide valuable tools to study these prodromal stages. We investigated various levels of genetic risk for AD using mice expressing the three...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e8e38bf-4c55-5493-892b-627dd87709fa
DOI: 10.1101/2025.02.05.636582

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse ModelsDOI 10.1101/2025.02.05.636582Read

APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity Read

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Semantic proximity Read

Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.Semantic proximity Read

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity Read

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s DiseaseSemantic proximity Read

Diffusion MRI in 2-Month-Old Mouse Brain Predicts Alzheimer's Pathology Genotype.Semantic proximity Read

Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceSemantic proximity Read

Global dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effectsSemantic proximity Read

The interaction effects of age, APOE and common environmental risk factors on human brain structure.Semantic proximity Read

The Interaction Effects of Age, APOE and Common Environmental Risk Factors on Human brain StructureSemantic proximity Read

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the humanSemantic proximity Read

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.Semantic proximity Read