Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s Disease

10 Dec 2019

Abstract excerpt

The major genetic risk for late onset Alzheimer’s disease has been associated with the presence APOE4 alleles. However, the impact of different APOE alleles on the brain aging trajectory, and how they interact with the brain local environment in a sex specific manner is not entirely clear. We sought to identify vulnerable brain circuits in novel mouse models with homozygous targeted replacement of the mouse ApoE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31920610
DOI: 10.3389/fninf.2019.00072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s DiseasePMID 31920610Read ↗

APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity Read ↗

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Semantic proximity Read ↗

Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceSemantic proximity Read ↗

Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.Semantic proximity Read ↗

Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse ModelsSemantic proximity Read ↗

Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous miceSemantic proximity Read ↗

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity Read ↗

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read ↗

Feature attention graph neural network for estimating brain age and identifying important neural connections in mouse models of genetic risk for Alzheimer’s diseaseSemantic proximity Read ↗

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the humanSemantic proximity Read ↗

Vulnerable Brain Networks Associated with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Diffusion MRI in 2-Month-Old Mouse Brain Predicts Alzheimer's Pathology Genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.