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Article

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.

Neuroscience - 1 Jun 2018

East Brett S, Fleming Gloria, Peng Kathy, Olofsson Jonas K, Levy Efrat, Mathews Paul M, Wilson Donald A

Abstract excerpt

Apolipoprotein E (ApoE) is an important lipid carrier in both the periphery and the brain. The ApoE ε4 allele (ApoE4) is the single most important genetic risk-factor for Alzheimer's disease (AD) while the ε2 allele (ApoE2) is associated with a lower risk of AD-related neurodegeneration compared to the most common variant, ε3 (ApoE3). ApoE genotype affects a variety of neural circuits; however, the olfactory...

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Identifiers

PMID: 29678753
DOI: 10.1016/j.neuroscience.2018.04.009
PMCID: PMC5959295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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