Article

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in model organisms can validate these associations and elucidate the links between specific genetic factors and transcriptomic signatures. Animal models based on LOAD-asso...

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Literature Corpus work: 633cb4b9-5629-5665-bc0b-5e7614783149
DOI: 10.1101/757161

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