Article

Local inhibition of PRC2 activity by H3.3K27M drives DNA replication defects through misregulation of the JNK pathway

2019-01-21

Abstract excerpt

Substitution of lysine 27 with methionine in histone H3.3 is a recently discovered driver mutation of pediatric high-grade gliomas. Mutant tumor cells show decreased levels and altered distribution of H3K27me3. How these chromatin changes are established genome-wide and lead to tumorigenesis only in specific tissues remains unclear. Here we show that H3.3K27M-mediated alterations in H3K27me3 distribution result in...

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Literature Corpus work: e1ee9e5a-a5aa-5017-a566-6d7fc3c4b934
DOI: 10.1101/525766

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