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The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

9 Nov 2021

Abstract excerpt

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliomas also exhibit high levels of copy number alterations, we set out to address if the H3.3K27M oncohistone leads to destabilization of the genome. Hereto, we...

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PMID: 34752469
DOI: 10.1371/journal.pgen.1009868

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