Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H3.3 maintains genome integrity during mammalian development.

Genes & development - 1 Jul 2015

Jang Chuan-Wei, Shibata Yoichiro, Starmer Joshua, Yee Della, Magnuson Terry

Abstract excerpt

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans and has been implicated in many important biological processes, including cell differentiation and reprogramming. Germline and somatic mutations in H3.3 genomic incorporation pathway components or in H3.3 encoding genes have been associated with human congenital diseases and cancers, respectively. However, the role of H3.3 in mammalian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Fertility
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Genomic Instability

Share to Growth and Development

Share to Heterochromatin

Share to Histones

Source

Open in PubMed Open full text

Identifiers

PMID: 26159997
DOI: 10.1101/gad.264150.115
PMCID: PMC4511213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H3.3 maintains genome integrity during mammalian development.PMID 26159997Read ↗

Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation developmentSemantic proximity Read ↗

Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.Semantic proximity Read ↗

The double face of the histone variant H3.3.Semantic proximity Read ↗

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.Semantic proximity Read ↗

Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.Semantic proximity Read ↗

Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory.Semantic proximity Read ↗

Global H3.3 dynamic deposition defines its bimodal role in cell fate transitionSemantic proximity Read ↗

Histone Variant H3.3: A versatile H3 variant in health and in disease.Semantic proximity Read ↗

Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.Semantic proximity Read ↗

Histone H3 mutations and their impact on genome stability maintenance.Semantic proximity Read ↗

Epigenetic and replacement roles of histone variant H3.3 in reproduction and development.Semantic proximity Read ↗

New functions for an old variant: no substitute for histone H3.3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.