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Article

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs.

Cell reports - 18 Oct 2016

Piazzesi Antonia, Papić Dražen, Bertan Fabio, Salomoni Paolo, Nicotera Pierluigi, Bano Daniele

Abstract excerpt

Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that...

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Identifiers

PMID: 27760329
DOI: 10.1016/j.celrep.2016.09.074
PMCID: PMC5081402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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