Article

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

2020-05-19

Abstract excerpt

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show that the genomic distributions of H3.1 and H3.3 oncohistones in human patient-derived DMG cells are consistent with t...

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Literature Corpus work: 4a0faf26-9fb0-5c16-9021-693d49a169f5
DOI: 10.1101/2020.05.18.101709

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